DR. GEORGE P YANG, MD, PHD
Radiology at Miranda Ave, Palo Alto, CA
License number
California A55161
Category
Radiology
Type
Surgery
Address
Address
3801 Miranda Ave, Palo Alto, CA 94304
Phone
(650) 852-6126
(650) 725-5644
(650) 736-1705 (Fax)
(650) 725-5644
(650) 736-1705 (Fax)
Professional information
George P Yang, Stanford CA
Specialties:
Surgery
Work:
Stanford University
300 Pasteur Dr, Stanford, CA 94305
300 Pasteur Dr, Stanford, CA 94305
Education:
Northwestern University (1994)
Methods Of Monitoring Endoplasmic Reticulum (Er) Stress Response
US Patent:
2012020, Aug 9, 2012
Filed:
Aug 10, 2010
Appl. No.:
13/389765
Inventors:
Albert C. Koong - Los Altos CA, US
Michael T. Spiotto - Chicago IL, US
George P. Yang - Stanford CA, US
Michael T. Spiotto - Chicago IL, US
George P. Yang - Stanford CA, US
Assignee:
The Board of trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61K 38/07, A61K 49/00, A01K 67/027, C12N 5/10, C12Q 1/66
US Classification:
514 201, 435349, 435325, 435350, 435351, 435363, 435352, 435353, 435354, 435355, 435356, 435357, 435 8, 800 9, 800 10, 800 12, 800 3
Abstract:
Transgenic mammals, cells derived from the animals, and methods of using these to monitor the endoplasmic reticulum (ER) stress response are provided. In some embodiments, the methods allow for monitoring the ER stress response in real time. Some of the methods allow non-invasive in vivo visualization of ER stress response. Also provided are methods of screening molecules and/or treatment conditions for the ability to modulate the ER stress response, methods of treating diseases characterized by ER stress response activity, and methods of detecting the toxicity or therapeutic ratio of molecules that modulate the ER stress response.