Inventors:
Ewa Carrier - La Jolla CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
C12N 5/0789, C12N 5/0775, C12N 5/0735
US Classification:
435347, 435373, 435372, 435363, 435355, 435353, 435352, 435350, 435351, 435377
Abstract:
The invention provides compositions for making erythroid progenitor cells that comprise in vitro-activated bone marrow mesenchymal stem cells and embryoid bodies (EBs) or pluripotent stem cells, and methods for making and using them, including ameliorating (e.g., preventing or treating) anemia and/or stimulating erythropoiesis. In one embodiment, the invention provides methods of increasing propensity of committed stem cell differentiation towards the erythroid lineage.