Inventors:
Justin R. Fallon - Providence RI, US
Beth McKechnie - Franklin MA, US
Michael Rafii - La Jolla CA, US
Hilliary Creely - Providence RI, US
Mark A. Bowe - Damascus MD, US
Alison Amenta - Pawtucket RI, US
Mary Lynn Mercado - Robbinsville NJ, US
Hiroki Hagiwara - Tokyo, JP
Assignee:
Brown University Research Foundation - Providence RI
International Classification:
A61K 38/00, A61K 45/00, A61K 39/00, A01N 37/18
US Classification:
514 177, 514 76, 514 83, 514 165, 514 179, 4242791, 4241841, 4241851, 4241921
Abstract:
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e. g. , to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.