Inventors:
Edward C. Dempsey - Aurora CO, US
International Classification:
A61K 38/48, A61P 11/00, A61P 9/00, A61P 9/12, G01N 33/573, C12Q 1/68, C12Q 1/37, A61K 48/00, A61P 29/00
US Classification:
424 9467, 514 44 R, 435 74, 435 613, 435 612, 435 23, 435 618
Abstract:
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming from the inventor's discovery that Neprilysin is expressed at reduced levels in disease tissues.