DONALD S PROUGH, MD
Anesthesiologist Assistant at University Blvd, Galveston, TX

6751490, Jun 15, 2004

Mar 1, 2001

09/796992

Rinat Esenaliev - Galveston TX
Massoud Motamedi - Houston TX
Donald Prough - Galveston TX

The Board of Regents of the University of Texas System - Austin TX

A61B 500

600310, 600322, 606 2

An optoacoustic apparatus is disclosed which includes a radiation source of pulsed optical radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.

2007023, Oct 4, 2007

Mar 13, 2007

11/685574

Donald Prough - Galveston TX, US
Rinat Esenaliev - League City TX, US
Massoud Motamedi - Houston TX, US

The Board of Regents of The University of Texas System - Austin TX

A61B 5/00

600316000

New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.

2008025, Oct 16, 2008

Apr 11, 2008

12/101891

Donald S. Prough - Galveston TX, US
Rinat O. Esenaliev - League City TX, US
Donald Deyo - Galveston TX, US
Yuriy Y. Petrov - Galveston TX, US
Irina Y. Petrova - Galveston TX, US

The Board of Regents of The University of Texas Syatem - Austin TX

A61B 5/145

600301, 600310

An optoacoustic technique for absolute, accurate, continuous, and real-time measurement of a variety of important diagnostic variables is disclosed, where the variables include: (1) noninvasive measurements of circulating blood volume (BV) and cardiac output (CO); (2) calculation from the measured variables of cardiac index (CI) and systemic oxygen delivery (DO); (3) concentrations of hemoglobin derivatives (e.g., carboxyhemoglobin [HbCO], reduced hemoglobin [Hb], oxygenated hemoglobin [HbOxy], and methemoglobin [HbMet]), total hemoglobin concentration [THb], concentrations of lactate, myoglobin, cholesterol, body pigments, and exogenous dyes; (4) content in tissues of water, fat, protein, calcium, and blood; as well as density of hard and soft tissues; and (5) accurate noninvasive measurement of blood pressure (or vascular pressure) in arteries, arterioles, veins, capillaries, using occlusion-induced changes in optoacoustic signal induced in blood circulating in the vessels. The optoacoustic technique can be used for single measurement, continuous measurement, or continuous monitoring of these variables.

2007023, Oct 4, 2007

Mar 13, 2007

11/685677

Rinat Esenaliev - League City TX, US
Donald Prough - Galveston TX, US

The Board of Regents of The University of Texas Syatem - Austin TX

A61B 5/00

600316000

A new OCT system and method are disclosed, where the system includes a probe equipped with a heating element and a high heat conductive member to warm a tissue site to be scanned to an elevated and/or to maintain the elevated tissue temperature with a temperature variation of less than or equal to 1° C. to improve an accuracy and reliability of an OCT glucose concentration value other long measurement durations. The new OCT system and method can also be equipped with pressure components to reduce a pressure exerted on the tissue site to a minimal constant pressure.

2012017, Jul 5, 2012

Mar 9, 2012

13/416963

Rinat O. Esenaliev - League City TX, US
Donald S. Prough - Galveston TX, US

A61B 5/145, A61B 5/1455, A61B 8/08

600316, 600365, 600438

New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.

2009031, Dec 17, 2009

Apr 28, 2006

11/919527

Joaquin Cortiella - Galveston TX, US
Joan E. Nichols - Galveston TX, US
Jean A. Niles - Galveston TX, US
Eric Lee - Houston TX, US
Donald Prough - Galveston TX, US

A61K 35/12, C12N 5/08, A61K 38/20, A61K 9/14

424484, 435372, 424 937, 424 852

The present invention is directed to developing treatment for spinal cord injury, traumatic brain injury and neural disease using autologous somatic stem cells isolated from peripheral blood. The method identified in the present invention will generate functional neural cells/tissues in order to replace the diseased or damaged neural cells/tissues. In doing so, the cells will not only reverse the motor as well as cognitive dysfunction but will also stabilize the injury site, reduce inflammation and scaring, and halt progressive loss of functional tissue. Further, this method also holds a great promise since it is non-invasive, autologous and can be used acutely.

2012020, Aug 9, 2012

Jul 9, 2011

13/179482

Donald S. Prough - Galveston TX, US
Rinat O. Esenaliev - League City TX, US
Daneshvari R. Solanki - League City TX, US
Michael Kinsky - League City TX, US
Yuriy Petrov - Galveston TX, US
Irene Petrov - Galveston TX, US

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

A61M 16/04, A61B 6/00

600424

Indwelling medical apparatus including one optoacoustic discernible member or a plurality of optoacoustic discernible members and methods for optoacoustic guidance and confirmation of placement of optoacoustically discernible indwelling medical apparatus.

7430445, Sep 30, 2008

Apr 26, 2004

10/554149

Rinat O. Esenaliev - League City TX, US
Donald S. Prough - Galveston TX, US

The Board of Regents of the University of Texas System - Austin TX

A61B 5/1455

600344, 600310, 600322, 600340

A method for analysis of blood components or parameters is disclosed where a probe having an excitation outlet and a response inlet is placed in proximity to or in contact with a tissue of an underside of a patient's tongue over a big vein in the tongue so that an excitation signal exits the outlet, produces a response which enters the inlet for detection and analysis.