Inventors:
Randall M. Goldblum - Dickinson TX
Srinivasan Rajaraman - Galveston TX
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
G01N 33543, G01N 33566
Abstract:
Methods of monitoring and detecting the early onset of organ injury incident rejection of an organ rejection in an animal are disclosed. The described methods are capable of distinguishing organ rejection injury from other organ tissue damage in the animal. Free secretory component levels in an animal biological fluid (e. g. , bile, urine, blood, amniotic fluid) may be used to identify organ rejection in an animal. Multiple and single organ transplant patients may be monitored and diagnosed according to the claimed methods. Biological fluids, such as blood, (serum) or urine, are analyzed immunologically using a particularly adapted ELISA which are then compared to an FSC control concentration to identify elevated FSC values. Animals with test FSC above FSC control concentrations are diagnosed as having an ongoing organ rejection episode. The detection of congenital renal dysfunction in utero is also provided according to the present invention through the measurement of FSC in the amniotic fluid.