DAVID R HOLMES, M.D.
Osteopathic Medicine at 1 St, Rochester, MN

6193670, Feb 27, 2001

Dec 22, 1998

9/218482

Robert A. Van Tassel - Excelsior MN
Robert S. Schwartz - Rochester MN
David Holmes - Rochester MN
Mark A. Rydell - Golden Valley MN

Tricardia, LLC - Excelsior MN

A61B 500

600486

An instrument for achieving rapid hemostasis at the conclusion of a catheterization procedure comprising a hemostatic agent injection device for use with a conventional introducer sheath used to gain access to the blood vessel. The injection device includes an elongated tubular member having ejection ports proximate its distal end. A hub member includes an elongated groove or track located in its surface with a transparent cover. The enclosed track is sealed from the lumen extending through the tubular member with a compliant membrane and filled with a predetermined amount of fluid. After the catheterization procedure, the device is inserted into the introducer sheath. Blood flows into the lumen of the device and pulsates against the compliant membrane. The fluid in the track pulsates within the enclosed track, clearly indicating that the ports are located in the blood vessel and subjected to variations in blood pressure. The instrument and introducer sheath are then slowly retracted as a unit in the puncture wound.

2007006, Mar 22, 2007

Sep 5, 2006

11/516020

Cheryl Conover - Rochester MN, US
Antonio Bayes-Genis - Barcelona, ES
David Holmes - Rochester MN, US
Robert Schwartz - Rochester MN, US

G01N 33/53

435007100

Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.

2002013, Sep 19, 2002

Jan 12, 2001

09/760376

Cheryl Conover - Rochester MN, US
Antonio Bayes-Genis - Barcelona, ES
David Holmes - Rochester MN, US
Robert Schwartz - Rochester MN, US

C12Q001/68

435/007920, 436/500000

Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.

6652556, Nov 25, 2003

Oct 26, 2000

09/697628

Robert A. VanTassel - Excelsior MN
Robert G. Hauser - Long Lake MN
Robert Schwartz - Rochester MN
David Holmes - Rochester MN
Gregg S. Sutton - Maple Grove MN
Thomas E. Borillo - Plymouth MN
Jeffrey Welch - New Hope MN

Atritech, Inc. - Minneapolis MN

A61M 2900

606200

Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure comprising a plurality of fingers which are radially outwardly expandable with respect to a longitudinal axis to permanently engage the interior wall of the left atrial appendage, wherein the filtering membrane is attached to the support structure extending across the ostium of the left atrial appendage.

2004012, Jun 24, 2004

Sep 4, 2003

10/656647

Robert VanTassel - Excelsior MN, US
Robert Hauser - Long Lake MN, US
Robert Schwartz - Rochester MN, US
David Holmes - Rochester MN, US
Gregg Sutton - Maple Grove MN, US
Thomas Borillo - Plymouth MN, US
Jeffrey Welch - New Hope MN, US

Atritech, Inc.

A61M029/00

606/200000

Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

2005028, Dec 29, 2005

Sep 2, 2005

11/218700

Robert VanTassel - Excelsior MN, US
David Holmes - Rochester MN, US
Robert Schwartz - Rochester MN, US

A61M031/00

604506000, 604272000

The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

5573520, Nov 12, 1996

Oct 26, 1994

8/329691

Robert S. Schwartz - Rochester MN
David R. Holmes - Rochester MN
Frederick S. Halverson - North Oaks MN
James V. Donadio - Chaska MN
David Berry - Longmont CO

Mayo Foundation for Medical Education and Research - Rochester MN

A61M 2500

604282

An apparatus for use as a catheter, a guidewire, a catheter sheath for use with catheter introducers or a drug infusion catheter/guidewire. The apparatus includes a flexible tubular member with an encasing covering the tubular member that creates a fluid-tight seal around the periphery of the tubular member. The tubular member is self-supporting and includes a plurality of apertures therein in a predetermined configuration to increase the flexibility of the tubular member.

5741429, Apr 21, 1998

May 31, 1995

8/455331

James V. Donadio - Chaska MN
David R. Holmes - Rochester MN
Robert S. Schwartz - Rochester MN
David Berry - Longmont CO

Cardia Catheter Company - St. Paul MN

B44C 122, C23F 102, A61M 2500

216 8

Manufacturing processes for apparatus, including slotted hypotube, for use as a catheter, a guidewire, a catheter sheath for use with catheter introducers or a drug infusion catheter/guidewire are disclosed. The manufacturing process includes creating a pattern of slots or apertures in a flexible metallic tubular member, by processes including but not limited to, electrostatic discharge machining (EDM), chemical milling, ablation and laser cutting. These slots or apertures may be cut completely or partially through the wall of the flexible metallic tubular member. These manufacturing processes may include the additional step of encasing the flexible metallic member such that a fluid tight seal is formed around the periphery of the tubular member.

5895376, Apr 20, 1999

Oct 23, 1996

8/735521

Robert S. Schwartz - Rochester MN
David R. Holmes - Rochester MN
David Berry - Longmont CO
Donald G. Ellis - Boulder CO

Mayo Foundation for Medical Education and Research - Rochester MN

A61M 500

604256

A hemostasis valve including a collapsible membrane in a portion of a through-lumen. Fluid pressure in a chamber surrounding the collapsible membrane assists in sealing the collapsible membrane around an operating device inserted through the hemostasis valve. Different mechanisms for mechanically deforming the collapsible membrane to assist in sealing are disclosed. Also, a system for continuously flushing a vascular catheter connected to a hemostasis valve at a rate of 0. 10 to 10. 0 cubic centimeters per minute, and a hemostasis valve assembly including an expandable reservoir which stores liquid volume under pressure.

2005020, Sep 22, 2005

May 27, 2005

11/140641

Noel Caplice - Rochester MN, US
David Berry - Sante Fe NM, US
Robert Schwartz - Rochester MN, US
David Holmes - Rochester MN, US
Robert Simari - Rochester MN, US

A61K048/00, C12N009/10, A61F002/00

424423000, 424093200, 623001110

Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.