Inventors:
Robert J. Ryan - Rochester MN
Daniel J. McCormick - Rochester MN
John C. Morris - Rochester MN
M. Cristine Charlesworth - Rochester MN
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
C07K 708, C07K 1514, A61K 3738, A61K 3702
Abstract:
Synthetic peptides corresponding to. alpha. -subunit of human glycoprotein hormone amino acid regions. alpha. 31-45,. alpha. 21-35,. alpha. 26-46 and. alpha. 81-92; were found to inhibit binding of 125. sub. I-bTSH to human thyroid. Peptides corresponding to regions. alpha. 26-46 and. alpha. 31-45 were also found to potently inhibit the stimulation of adenylate cyclase activity by bTSH in a TSH bioassay using FRTL-5 cells and block the action of thyroid stimulating immunoglobulin.