DR. DAVID PATTERSON HENRY, M. D.
Osteopathic Medicine at Burrington, Chapel Hill, NC

License number

North Carolina 01025648A

Personal information

See more information about DAVID PATTERSON HENRY at radaris.com

Name

Address

Phone

David Henry, age 44

5001 Bridget Dr, Raleigh, NC 27603

(919) 771-1315

David Henry, age 68

4720 Friar Ave, Fayetteville, NC 28304

(910) 443-2692

David Henry

5205 Rivington Rd, Fuquay Varina, NC 27526

Professional information

Glyoxylic Acid Hydrocarbylsulfonylhydrazones And Therapeutic Compositions

US Patent:

4218465, Aug 19, 1980

Filed:

Apr 17, 1978

Appl. No.:

5/887474

Inventors:

Edward W. Grange - Palo Alto CA
David W. Henry - Chapel Hill NC
William W. Lee - Palo Alto CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3138, A61K 3116, A61K 3115, C07O33324

US Classification:

424275

Abstract:

Glyoxylic acid hydrocarbylsulfonylhydrazones and therapeutic compositions containing the same. Said compounds are useful in treating cancer, they being active against leukemia P-388, for example.

N,N-Pentamethylene Derivatives Of Daunomycin And Adriamycin

US Patent:

4202967, May 13, 1980

Filed:

Oct 2, 1978

Appl. No.:

5/947463

Inventors:

George L. Tong - Cupertino CA
David W. Henry - Chapel Hill NC
Helen Y. Wu - San Jose CA
Thomas H. Smith - San Carlos CA

Assignee:

SRI International - Menlo Park CA

International Classification:

C07H 1524

US Classification:

536 17A

Abstract:

Described are N,N-pentamethylene derivatives of daunomycin and adriamycin having the formula: ##STR1## wherein R. sup. 1 is --COCH. sub. 3 or --CHOHCH. sub. 3 in the case of daunomycin derivatives, or --COCH. sub. 2 OH or --CHOHCH. sub. 2 OH in the case of adriamycin derivatives. The compounds have utility as antitumor agents.

Mesoionic Antitumor Compositions And Methods For Using The Same In The Treatment Of Cancer

US Patent:

4329355, May 11, 1982

Filed:

Mar 1, 1979

Appl. No.:

6/016384

Inventors:

David W. Henry - Chapel Hill NC
Kenneth J. Ryan - Sunnyvale CA
Edward W. Grange - Palo Alto CA

International Classification:

A61K 3142

US Classification:

424272

Abstract:

Mesoionic anhydro-5-amino-1,2,3,4-oxatriazolium hydroxides and methods of using the same in the treatment of cancer, said compositions containing, as an active ingredient, one or more compounds having the structure ##STR1## wherein R. sup. 1 represents a phenyl or substituted phenyl group and R. sup. 2 represents hydrogen or a methyl group.

Bis-Hydrazones Of Daunomycin And Adriamycin

US Patent:

4112217, Sep 5, 1978

Filed:

Sep 2, 1977

Appl. No.:

5/830091

Inventors:

David W. Henry - Chapel Hill NC
George L. Tong - Cupertino CA

Assignee:

SRI International - Menlo Park CA

International Classification:

C07G 300

US Classification:

536 4

Abstract:

Bis-hydrazones of daunomycin and adriamycin having useful antitumor characteristics and the structure ##STR1## WHEREIN N IS AN INTEGER HAVING A VALUE OF FROM 0 THROUGH 8 AND THE RADICALS INDICATED BY R and R' each represent hydrogen except that in those instances in which n has a value of 2, the R groups, if not hydrogen, may be methyl radicals (with R' remaining as hydrogen), and the R' groups, if not hydrogen, may be hydroxy radicals (with R remaining as hydrogen).

Octanoylhydrazone Derivatives Of Adriamycin

US Patent:

4291157, Sep 22, 1981

Filed:

Jul 22, 1980

Appl. No.:

6/171083

Inventors:

David W. Henry - Chapel Hill NC
George L. Tong - Cupertino CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3171, C07H 1524

US Classification:

536 17A

Abstract:

Adriamycin octanoylhydrazone, and its pharmaceutically acceptable salts, having good antitumor activity coupled with low toxicity.

Phenyl-Substituted Rubidazone Analogs

US Patent:

4125704, Nov 14, 1978

Filed:

Sep 14, 1977

Appl. No.:

5/833165

Inventors:

David W. Henry - Chapel Hill NC
George L. Tong - Cupertino CA

Assignee:

SRI International - Menlo Park CA

International Classification:

C07G 300

US Classification:

536 4

Abstract:

Rubidazone analogs wherein the phenyl group is substituted by one of 4-phenyl, 4-chloro, 3,4-dichloro or 3-nitro, said compounds having high antitumor activity coupled with desirably low cardiotoxicity.

N-Benzyl Anthracyclines

US Patent:

4177264, Dec 4, 1979

Filed:

Oct 2, 1978

Appl. No.:

5/947874

Inventors:

Helen Y. Wu - San Jose CA
Thomas H. Smith - San Carlos CA
David W. Henry - Chapel Hill NC

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3171, C07H 1524

US Classification:

424180

Abstract:

N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and daunomycin, said derivatives having anticancer properties and being active against leukemia P-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibiting a loss of DNA-binding properties.