Inventors:
John B. Buse - Chapel Hill NC, US
Kathleen Dungan - Columbus OH, US
Steven D. Wittlin - Rochester NY, US
Eric A. Button - Kannapolis NC, US
Shuhei Kato - Tokyo, JP
Toshio Tanabe - Tokyo, JP
Assignee:
Nippon Kayaku Kabushiki Kaisha - Tokyo
Toyota Tsusho America, Inc. - New York NY
International Classification:
C12Q 1/54
Abstract:
The invention is a method of measuring blood glucose excursions in general, and postprandial hyperglycemia in diabetic patients in particular, by the 1,5-anhydroglucitol assay (1,5-AG) or A1C/1,5-AG assay combination. 1,5-AG levels and percent changes of 1,5-AG levels in short period are indicative of differing postmeal glucose levels in moderately-controlled diabetic patients with similar A1C levels. Thereby 1,5-AG assay is useful to identify diabetic patients who may be at risk for cardiovascular complications which would not be identifiable by A1C levels alone. Furthermore, ratios of A1C divided by 1,5-AG in each patient are superior indicators to 1,5-AG levels.