Inventors:
David M. Briscoe - Sharon MA
Karen Moulton - Weston MA
Mohamed H. Sayegh - Westwood MA
Assignee:
Children's Medical Center Corporation - Boston MA
International Classification:
A61K 3800, A61K 3812, A61K 3813, A61K 31335, A01N 4320
Abstract:
The invention relates a method of inhibiting chronic allograft rejection in a subject with an organ transplant. The method comprises administering an effective amount of one or more anti-angiogenic agents to a subject alone or in combination with one or more immunosuppressive agents. The invention provides new and improved methods of inhibiting allograft rejection.