Inventors:
David A. Horne - New York NY
Noboru Kubodera - Tokyo, JP
Hiroshi Suzuki - Tokyo, JP
Hitoshi Shimizu - Tokyo, JP
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
Chugai Seiyaku Kabushiki Kaisha - Tokyo
International Classification:
C07C40300
US Classification:
540114, 549512, 549513, 549516, 549522, 552653
Abstract:
A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R and R independently is optionally substituted C -C alkyl; each of W and X is independently hydrogen or C -C alkyl; Y is O, S or NR where R is hydrogen, C -C alkyl or a protective group; and Z is a CD ring structure, a steroid structure, or a vitamin D structure, each of which optionally having structure (IV) wherein W, X, Y and Z are defined above, in the presence of a base, with a compound having structure (V) or (vâ²) wherein n, R and R are as defined above, and E is an eliminating group.