Inventors:
Charles F. Grose - Iowa City IA
Richard Santos - Iowa City IA
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
A61K 39245
US Classification:
4242291, 4242301, 4242041, 435 911, 435 9133, 435 89, 536 2372
Abstract:
The present invention provides methods directed to detecting antibodies that specifically bind to a varicella zoster polypeptide, detecting the presence of a varicella zoster virus in an animal, diagnosing a disease caused by varicella zoster virus, and detecting a varicella zoster virus having a single nucleotide polymorphism in ORF68. The present invention also provides a vaccine composition, a method for producing a modified attenuated varicella zoster virus, isolated polynucleotides, and isolated polypeptides, and viruses.