Inventors:
Lynda Chin - Brookline MA, US
Cameron W. Brennan - New York NY, US
Ronald A. DePinho - Brookline MA, US
Andrew J. Aguirre - Boston MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 39/395, C12Q 1/68, C40B 30/00, A01K 67/00, A61K 31/7052, A61K 38/02, A61K 38/16, C07K 14/00, C07H 21/00, C07K 16/00, A61P 35/00
US Classification:
4241721, 435 6, 506 7, 800 10, 4241831, 4241781, 514 44 A, 514 2, 514 12, 530350, 536 231, 5303891
Abstract:
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.