Inventors:
Betty Diamond - Bronx NY, US
Bruce Volpe - Bronx NY, US
International Classification:
A61K 38/08, A61K 38/10, A61K 38/16, A61K 39/395
US Classification:
424130100, 514012000, 514013000, 514014000, 514015000, 514016000, 514017000
Abstract:
Methods of preventing binding of an anti-double stranded (ds)-DNA antibody to a neuron in a mammal exhibiting or at risk for lupus-induced cognitive dysfunction are provided. Methods of inhibiting progression of cognitive dysfunction in a mammal exhibiting or at risk for lupus-induced cognitive dysfunction are also provided. Also provided are methods of inhibiting progression of cognitive dysfunction in a mammal exhibiting or at risk for lupus-induced cognitive dysfunction. Additionally, methods of inhibiting progression of cognitive dysfunction in a mammal exhibiting or at risk for lupus-induced cognitive dysfunction are provided. Further provided are methods of inducing cognitive dysfunction in a mammal, and nonhuman mammal treated with a DNA mimotope in such a manner to induce antibodies that bind to ds-DNA and an NR2 subunit of a neuron in the mammal, then, after the antibodies are induced, treated to temporarily open the blood brain barrier.