Inventors:
Brian Hoh - Gainesville FL, US
Chris Batich - Gainesville FL, US
Edward Scott - Gainesville FL, US
International Classification:
A61K 38/20, A61F 2/82, A61K 38/48, A61P 9/00, A61K 38/16
US Classification:
424 852, 623 142, 424 9467, 514 12
Abstract:
The present invention provides polymeric compositions, devices, and methods for repair of vascular injury, particularly endothelial injury and impaired vascular repair, such as from intracranial aneurysms and carotid atherosclerosis. The invention particularly provides polymers incorporating signaling factors useful for recruiting circulating vascular progenitor cells. The polymers can be used alone or as a coating for various devices for placement at sites of vascular injury to promote repair by the body's natural systems.