Inventors:
Michael D. P. Boyle - Whitehouse OH
Richard Lottenberg - Gainesville FL
Christopher Broder - Rockville MD
Gregory Von Mering - Gainesville FL
Assignee:
University of Florida Research Foundation, Inc. - Alachua FL
International Classification:
C07K 1500, A61K 3900
Abstract:
The subject invention concerns novel methods and compositions for thrombolytic therapy. More specifically, a receptor with high affinity for plasmin has been characterized, purified, cloned, and expressed. This receptor can be used in combination therapies where it is administered prior to, concurrently with, or after a plasminogen activator. Also, this receptor can be bound to plasmin and administered to humans or animals in need of fibrinolytic activity. Additionally, the invention pertains to a novel immobilized form of plasmin which advantageously accumulates at the point where antifibrinolytic activity is needed.