DR. BRIAN LEONARD LEVY, M.D.
Osteopathic Medicine at Warren St, New York, NY

2013027, Oct 24, 2013

Apr 18, 2013

13/865780

Cary J. Reich - Los Gatos CA, US
Yair Alster - Palo Alto CA, US
Matt Clarke - Mountain View CA, US
Brian Levy - New York NY, US
Raymond Lum - El Cerrito CA, US
Jose D. Alejandro - Sunnyvale CA, US

NexisVision, Inc. - Menlo Park CA

G02C 7/04

35115904, 35115902, 35115978

Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed.

2011007, Mar 24, 2011

Dec 14, 2010

12/967618

Steven Blum - New York NY, US
Barrett Katz - New York NY, US
Christopher Wilfong - New York NY, US
Brian Levy - New York NY, US

MESH THERAPEUTICS, LLC - New York NY

A61K 31/352, A61K 9/14, A61P 27/06

424489, 514456

A topical ophthalmic pharmaceutical formulation may include particles of the compound (2S,3S,4R)—N″-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine suspended in a solution comprising monobasic sodium phosphate monohydrate, disodium phosphate heptahydrate, edetate disodium, benzalkonium chloride, sodium chloride, polysorbate 80, and water. A method of treating glaucoma may include topically applying to the eye of a patient in need thereof a therapeutically effective amount of this formulation.

2013007, Mar 21, 2013

Oct 25, 2010

13/503842

Cary J. Reich - Los Gatos CA, US
Yair Alster - Palo Alto CA, US
K. Angela Macfarlane - Woodside CA, US
Doug Rimer - Los Altos Hills CA, US
Douglas Sutton - Pacifica CA, US
Dean Carson - Mountain View CA, US
Enrique Barragan - Monterrey CA, US
Matt Clarke - Menlo Park CA, US
Ashley Tuan - Menlo Park CA, US
Brian Levy - New York NY, US

NexisVision, Inc. - Menlo Park CA

A61F 9/00, G02C 7/04

35115923, 128858

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

8459793, Jun 11, 2013

Sep 13, 2012

13/615111

Cary J. Reich - Los Gatos CA, US
Yair Alster - Palo Alto CA, US
K. Angela Macfarlane - Woodside CA, US
Doug Rimer - Los Altos Hills CA, US
Douglas Sutton - Pacifica CA, US
Dean Carson - Mountain View CA, US
Enrique Barragan - Monterrey, MX
Matt Clarke - Menlo Park CA, US
Ashley Tuan - Menlo Park CA, US
Brian Levy - New York NY, US

NexisVision, Inc. - Menlo Park CA

A61B 3/14, A61B 3/00

351207, 351246

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

2012031, Dec 6, 2012

Jul 20, 2012

13/555056

Cary J. Reich - Los Gatos CA, US
Yair Alster - Palo Alto CA, US
K. Angela Macfarlane - Woodside CA, US
Doug Rimer - Los Altos Hills CA, US
Douglas Sutton - Pacifica CA, US
Dean Carson - Mountain View CA, US
Enrique Barragan - Monterrey, MX
Matt Clarke - Menlo Park CA, US
Ashley Tuan - Menlo Park CA, US
Brian Levy - New York NY, US

NixisVision, Inc. - Menlo Park CA

A61F 9/00

602 43

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.