Inventors:
Jane Salmon - New York NY, US
Guillermina Girardi - New York NY, US
V. Holers - Denver CO, US
Assignee:
New York Society for the Ruptured and Crippled Maintaining The Hospital for Special Surgery - New York NY
The Regents of the Universuty of Colorado - Boulder CO
International Classification:
A61K 38/08, A61K 38/10
US Classification:
514014000, 514015000, 514016000, 514017000
Abstract:
Described are methods for treating, preventing, or reducing the risk of, miscarriages, especially recurrent miscarriages. The methods comprise administering to a female subject a therapeutic agent that modulates the activity or binding of components of the complement system, together with a pharmaceutically acceptable carrier. For example, the therapeutic agent can be a C3-convertase inhibitor, an antibody against C5, an antagonist of the C5a receptor, or an antibody against factor B or factor D. Screening methods for agents that can prevent or reduce the risk of miscarriages, especially recurrent miscarriages, are also described.