Inventors:
Maria Carolina Delgado - Doral FL, US
Bertram Pitt - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 33/04, A61K 33/00, C12Q 1/02, A61K 31/585, A61K 31/546, A61K 31/4406, A61K 31/4155, A61K 31/41, A61K 31/4178, A61K 31/4168, A61K 31/403, A61K 31/40, A61K 31/355, A61K 31/197, A61K 31/135, A61K 31/138, A61K 31/04
US Classification:
424702, 424722, 435 29, 514173, 5142225, 514355, 514381, 514382, 514397, 514401, 514411, 514412, 514423, 514458, 514567, 514651, 514652, 514742
Abstract:
The present invention provides methods for measuring, detecting, diagnosing, treating, and researching salt sensitivity and related conditions. In particular, the present invention provides methods for measuring, detecting, diagnosing, treating, and researching salt sensitivity through measuring aberrant red blood cell based potassium efflux levels. In addition, the present invention provides methods for treating conditions involving salt sensitivity (e.g., hypertension), preventing the onset of conditions involving salt sensitivity, identifying individuals at risk for developing salt sensitivity and related conditions, identifying new types of treatment for salt sensitivity and related conditions, and evaluating the effectiveness of treatments for conditions involving salt sensitivity (e.g., hypertension).