Inventors:
George Coukos - Wynnewood PA, US
Ronald J. Buckanovich - Ann Arbor MI, US
Phyllis A. Gimotty - Philadelphia PA, US
International Classification:
A61K 51/00, A61K 49/00, A61K 39/395, A61K 31/7105, G01N 33/48, C12Q 1/04, C12Q 1/68, C07K 7/00, C07K 16/30
US Classification:
424 149, 424 91, 4241781, 514 44 A, 436 64, 435 34, 435 6, 530326, 5303879
Abstract:
This invention provides methods of detecting and localizing tumor vasculature cells (TVC) and solid tumors; and treating, impeding vascularization of, and determining the stage of solid tumors in a subject, comprising the step of contacting a subject or a TVC with a ligand that binds to a nucleic acid molecule of the present invention, or binds to a protein encoded by the nucleic acid molecule.