Inventors:
Lawrence Corey - Mercer Island WA, US
Kerry J. Laing - Seattle WA, US
Anna Wald - Seattle WA, US
David M. Koelle - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
University of Washington - Seattle WA
International Classification:
A61K 39/245, C12N 15/63, C12N 1/21, C12P 21/02, A61P 37/04, C07K 7/08, C12N 7/01, C12N 5/0783, A61P 31/22, C12N 15/38, C07K 7/06
US Classification:
4241861, 536 2372, 4353201, 4352523, 435 693, 530328, 530326, 4352351, 435375
Abstract:
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV, The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.