ANIL VACHANI
Medical Practice in Merion Station, PA
License number
Pennsylvania MD066508L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Merion Station, PA 19066
Personal information
See more information about ANIL VACHANI at radaris.comName
Address
Phone
127 Catharine St, Philadelphia, PA 19147
506 Narberth Ave, Merion Sta, PA 19066
Professional information
Method For Diagnosing Lung Cancers Using Gene Expression Profiles In Peripheral Blood Mononuclear Cells
US Patent:
2014000, Jan 2, 2014
Filed:
Jun 11, 2013
Appl. No.:
13/914902
Inventors:
Malik Yousef - Dabburiya Village, IL
Steven M. Albelda - Bala Cynwyd PA, US
Anil Vachani - Merion Station PA, US
Andrei V. Kossenkov - Huntingdon Valley PA, US
Steven M. Albelda - Bala Cynwyd PA, US
Anil Vachani - Merion Station PA, US
Andrei V. Kossenkov - Huntingdon Valley PA, US
International Classification:
C12Q 1/68
US Classification:
506 9, 506 16, 506 18
Abstract:
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile.
Method For Diagnosing Lung Cancers Using Gene Expression Profiles In Peripheral Blood Mononuclear Cells
US Patent:
8476420, Jul 2, 2013
Filed:
Dec 5, 2008
Appl. No.:
12/745991
Inventors:
Michael Showe - Media PA, US
Louise Showe - Media PA, US
Malik Yousef - Dabburiya Village, IL
Steven M. Albelda - Bala Cynwyd PA, US
Anil Vachani - Merion Station PA, US
Andrei V. Kossenkov - Huntingdon Valley PA, US
Louise Showe - Media PA, US
Malik Yousef - Dabburiya Village, IL
Steven M. Albelda - Bala Cynwyd PA, US
Anil Vachani - Merion Station PA, US
Andrei V. Kossenkov - Huntingdon Valley PA, US
Assignee:
The Wistar Institute of Anatomy and Biology - Philadelphia PA
The Trustees of the University of Pennsylvania - Philadelphia PA
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/11, C12N 15/113, C12N 15/12, C07H 21/04, C12Q 1/68
US Classification:
536 243, 536 231, 536 232, 536 235, 435 614
Abstract:
Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected genes, e. g. , a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile. Another composition for similar use contains a plurality of polynucleotides immobilized on a substrate, which probes hybridize to three or more gene expression products from genes in the gene expression profile. Still another composition involves detection of the protein expression products of genes from the gene expression profile.
Method For Distinguishing Between Head And Neck Squamous Cell Carcinoma And Lung Squamous Cell Carcinoma
US Patent:
2007026, Nov 15, 2007
Filed:
Nov 16, 2006
Appl. No.:
11/560410
Inventors:
Louise Showe - Media PA, US
Anil Vachani - Merion Station PA, US
Steven Albelda - Bala Cynwyd PA, US
Anil Vachani - Merion Station PA, US
Steven Albelda - Bala Cynwyd PA, US
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the lung and metastatic head and neck squamous cell carcinoma. These genes include CXCL13, COL6A2, SFTPB, KRT14, TSPYL5, TMP3, KLK10, MMP1, GAS1, and MYH2. A panel of one or more of these genes, or proteins encoded thereby, can be used for early diagnosis and selection of an appropriate therapeutic treatment.