ROBERT HERMAN VONDERHEIDE
Medical Practice in Merion Station, PA
License number
Pennsylvania MD417436
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Merion Station, PA 19066
Personal information
See more information about ROBERT HERMAN VONDERHEIDE at radaris.comName
Address
Phone
518 Lafayette Rd, Merion Sta, PA 19066
518 Lafayette Rd, Merion Station, PA 19066
Professional information
See more information about ROBERT HERMAN VONDERHEIDE at trustoria.com
Artificial Antigen Presenting Cells And Uses Therefor
Artificial Antigen Presenting Cells And Uses Therefor
US Patent:
7754482, Jul 13, 2010
Filed:
May 25, 2005
Appl. No.:
11/137807
Inventors:
James L. Riley - Downingtown PA, US
Carl H. June - Merion Station PA, US
Robert H. Vonderheide - Merion Station PA, US
Nicole Aqui - Philadelphia PA, US
Megan M. Suhoski - Philadelphia PA, US
Carl H. June - Merion Station PA, US
Robert H. Vonderheide - Merion Station PA, US
Nicole Aqui - Philadelphia PA, US
Megan M. Suhoski - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 5/00
US Classification:
435375, 435373, 435377, 424 932
Abstract:
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit.
Activation And Expansion Of T-Cells Using An Engineered Multivalent Signaling Platform As A Research Tool
Activation And Expansion Of T-Cells Using An Engineered Multivalent Signaling Platform As A Research Tool
US Patent:
8637307, Jan 28, 2014
Filed:
May 10, 2010
Appl. No.:
12/777053
Inventors:
Carl H. June - Merion Station PA, US
James L. Riley - Downingtown PA, US
Marcela Maus - Wynnewood PA, US
Anna Thomas - Freiburg, DE
Robert Vonderheide - Merion Station PA, US
James L. Riley - Downingtown PA, US
Marcela Maus - Wynnewood PA, US
Anna Thomas - Freiburg, DE
Robert Vonderheide - Merion Station PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 5/02, C12N 5/06, C12N 5/08, C12N 5/00, C07K 16/00
US Classification:
435325, 435326, 435355, 435372, 4353728
Abstract:
Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition, T cell proliferation can be induced without the need for antigen, thus providing an expanded T cell population that is polyclonal with respect to antigen reactivity. Further provided are methods for using the system and methods to screen and identify antigens related to specific diseases or conditions, tumors, autoimmune disorders, or an infectious disease or pathogen, and to identify target molecule for research purposes, or for developing a vaccine based thereon.
Novel Artificial Antigen Presenting Cells And Uses Therefor
Novel Artificial Antigen Presenting Cells And Uses Therefor
US Patent:
2011026, Oct 27, 2011
Filed:
Jun 8, 2010
Appl. No.:
12/796445
Inventors:
James L. Riley - Downingtown PA, US
Carl H. June - Merion Station PA, US
Robert H. Vonderheide - Merion Station PA, US
Nicole Aqui - Philadelphia PA, US
Megan M. Suhoski - Nuangola PA, US
Carl H. June - Merion Station PA, US
Robert H. Vonderheide - Merion Station PA, US
Nicole Aqui - Philadelphia PA, US
Megan M. Suhoski - Nuangola PA, US
International Classification:
C12N 5/10, A61P 31/18, A61K 39/00, A61P 35/00, C12N 5/078, C12Q 1/06
US Classification:
4241841, 435372, 435375, 435 39
Abstract:
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit.
Activation And Expansion Of T-Cells Using An Engineered Multivalent Signaling Platform As A Research Tool
Activation And Expansion Of T-Cells Using An Engineered Multivalent Signaling Platform As A Research Tool
US Patent:
7745140, Jun 29, 2010
Filed:
Jun 13, 2003
Appl. No.:
10/461283
Inventors:
Carl June - Merion Station PA, US
James Riley - Downingtown PA, US
Marcela Maus - Wynnewood PA, US
Anna Thomas - Freiburg, DE
Robert Vonderheide - Merion Station PA, US
James Riley - Downingtown PA, US
Marcela Maus - Wynnewood PA, US
Anna Thomas - Freiburg, DE
Robert Vonderheide - Merion Station PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 33/53, C12N 5/00, C12N 15/63, C07K 17/00
US Classification:
435 71, 435325, 435373, 435455
Abstract:
Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition, T cell proliferation can be induced without the need for antigen, thus providing an expanded T cell population that is polyclonal with respect to antigen reactivity. Further provided are methods for using the system and methods to screen and identify antigens related to specific diseases or conditions, tumors, autoimmune disorders, or an infectious disease or pathogen, and to identify target molecule for research purposes, or for developing a vaccine based thereon.
Human Anti-Cancer Immunotherapy
Human Anti-Cancer Immunotherapy
US Patent:
2006007, Apr 6, 2006
Filed:
May 25, 2005
Appl. No.:
11/137253
Inventors:
Robert Vonderheide - Merion Station PA, US
Gregory Beatty - Kennett Square PA, US
Christina Coughlin - Philadelphia PA, US
Gregory Beatty - Kennett Square PA, US
Christina Coughlin - Philadelphia PA, US
International Classification:
A61K 39/00, A61K 48/00
US Classification:
424185100, 514044000
Abstract:
The present invention encompasses compositions and methods for activating, stimulating and isolating antigen-specific T cells. The present invention also relates to compositions of antigen-specific T cells and methods of their use in the treatment and prevention of cancer, infectious diseases, autoimmune diseases, immune disfunction related to aging, or any other disease state where antigen-specific T cells are desired for treatment.
Activation And Expansion Of T-Cells Using An Engineered Multivalent Signaling Platform
Activation And Expansion Of T-Cells Using An Engineered Multivalent Signaling Platform
US Patent:
7638326, Dec 29, 2009
Filed:
Jun 13, 2003
Appl. No.:
10/462207
Inventors:
Carl June - Merion Station PA, US
James Riley - Downingtown PA, US
Marcela Maus - Wynnewood PA, US
Anna Thomas - Freiburg, DE
Robert Vonderheide - Merion Station PA, US
James Riley - Downingtown PA, US
Marcela Maus - Wynnewood PA, US
Anna Thomas - Freiburg, DE
Robert Vonderheide - Merion Station PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 5/02, C12N 5/06, C12N 15/00, C12N 15/63, C07K 16/00
US Classification:
435325, 435326, 435440, 435455
Abstract:
The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells using an engineered multivalent signaling platform. Compositions of cells activated and expanded by the methods herein are further provided.