Inventors:
Andrew L. Feldman - Rochester MN, US
Ahmet Dogan - Rochester MN, US
George Vasmatzis - Oronoco MN, US
Mark Law - Rochester MN, US
David I. Smith - Rochester MN, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
International Classification:
C40B 30/04, C12Q 1/42, G01N 33/573, C12Q 1/68
US Classification:
506 9, 435 618, 435 21, 435 71
Abstract:
This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.