Inventors:
Andrea L. Richardson - Chestnut Hill MA, US
Zhigang C. Wang - Chestnut Hill MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 39/395, C40B 30/04, G01N 33/566, A61P 35/00, A61K 31/704, C07H 21/00, C07K 16/18, C07H 21/02, C12Q 1/68, A61K 31/713
US Classification:
4241741, 435 611, 435 612, 506 9, 435 79, 4241781, 514 44 A, 514 34, 536 243, 5303897, 536 245
Abstract:
The present invention is based, in part, on the discovery that amplification of human chromosome 8q22-23 regions and over-expression of 8q22-23 genes (e.g., LAPTM4B and YWHAZ) is associated with and predictive of resistance to anthracycline-type chemotherapy. Accordingly, the invention relates to compositions, kits, and methods for predicting the response of cancer cells, e.g., breast, prostate, lung, ovarian, pancreatic, liver, and colon malignancies to anthracyclines.