Inventors:
Ali Gharavi - New York NY, US
Krzysztof Kiryluk - New York NY, US
International Classification:
C12Q 1/68
US Classification:
514 44 A, 435 611, 514169, 506 9, 506 16, 702 19
Abstract:
Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating subjects at risk of developing IgA neuropathy based on a new seven-SNP genetic risk score. Also provided are screening methods to identify compounds that bind to and reduce the expression or biological activity of a either CFHR1 or CFHR3.