DR. KURT STENZEL, M.D.
Osteopathic Medicine at 70 St, New York, NY

6818230, Nov 16, 2004

Jan 3, 2003

10/336313

Shirin Asina - New York NY
Kanti Jain - New York NY
Albert L. Rubin - Englewood NJ
Barry Smith - New York NY
Kurt Stenzel - New York NY

The Rogosin Institute - New York NY

A61K 3512

424520, 424 937, 435177, 435178, 435182, 435382, 435395

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

6224912, May 1, 2001

Nov 9, 1998

9/188476

Shirin Asina - New York NY
Kanti Jain - New York NY
Albert L. Rubin - Englewood NJ
Barry Smith - New York NY
Kurt Stenzel - New York NY

The Rogo Institute - New York NY

A61K 3512, C12N 1110, C12N 1104, C12N 506, C12N 508

424520

A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells.

5888497, Mar 30, 1999

Nov 7, 1996

8/745063

Kanti Jain - New York NY
Albert L. Rubin - Englewood NJ
Shirin Asina - New York NY
Barry Smith - New York NY
Kurt Stenzel - New York NY

The Rogosin Institute - New York NY

A01N 6300, C12N 1110, C12N 506, C12N 508

424 937

Implantable beads which contain agarose and optionally collagen, and are coated with agarose have incorporated within cells which produce diffusible biological products. The beads may be used as implants to modulate a recipient's immune response. The beads may also be used in an in vitro context to encourage specific types of cells to grow, to produce desirable products in culture, or to suppress growth of certain cells. The implants may also suppress growth of certain cells following administration to a subject. Cancer cells such as renal cancer cells when restricted by being entrapped in the beads produce more of a material that suppresses cancer cell proliferation.

7838291, Nov 23, 2010

Aug 10, 2007

11/891526

Bryan Conn - New York NY, US
Barry Smith - New York NY, US
Albert L. Rubin - Engelwood NJ, US
Kurt Stenzel - New York NY, US

The Rogosin Institute - New York NY

C12N 5/00, C12N 5/02

435374, 435375, 435377, 435382, 435395

The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

7297331, Nov 20, 2007

Aug 16, 2004

10/919767

Shirin Asina - New York NY, US
Kanti Jain - New York NY, US
Albert L. Rubin - Englewood NJ, US
Barry Smith - New York NY, US
Kurt Stenzel - New York NY, US

The Rogosin Institute - New York NY

A61K 35/12, C12N 11/02, C12N 11/10, C12N 5/00, C12N 5/08

424 937, 435177, 435178, 435182, 435366, 435382, 435395, 435397

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

7041504, May 9, 2006

Dec 12, 2000

09/735073

Shirin Asina - New York NY, US
Kanti Jain - New York NY, US
Albert L. Rubin - Englewood NJ, US
Barry Smith - New York NY, US
Kurt Stenzel - New York NY, US

The Rogosin Institute - New York NY

C12N 5/06, C12N 5/08, C12N 11/10, C12N 11/04, A61K 35/12

435382, 424 937, 424520, 435177, 435178, 435182, 435395

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

2011027, Nov 10, 2011

Jun 9, 2011

13/156659

Bryan CONN - New York NY, US
Barry Smith - New York NY, US
Albert L. Rubin - Engelwood NJ, US
Kurt Stenzel - New York NY, US
Marc Rubin - , US

C12N 5/071, C12N 5/0735

435404

The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

2007011, May 17, 2007

Jan 8, 2007

11/650782

Shirin Asina - New York NY, US
Kanti Jain - New York NY, US
Albert Rubin - Englewood NJ, US
Barry Smith - New York NY, US
Kurt Stenzel - New York NY, US

A61K 39/00

424277100

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.