Inventors:
Gundo Diedrich - South San Francisco CA, US
Shu-Hui Liu - Redwood City CA, US
Agnes Nowakowski - Austin TX, US
Assignee:
diaDexus, Inc. - South San Francisco CA
International Classification:
C07K 16/18, C12N 9/96
US Classification:
800 18, 4241521, 4241781, 435 723, 435 696, 435188, 435332, 435375, 4353201, 5303873, 5303882, 5303913, 5303917, 536 2353
Abstract:
Isolated antibodies and antigen binding fragments thereof directed against Ovr110 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovr110-expressing cancer cells and alleviating or treating an Ovr110-expressing cancer in a mammal. The anti-Ovr110 antibodies modulate Ovr110 function or internalize upon binding to Ovr110 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovr110 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovr110 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.