AARON TOMER, M.D.
Medical Practice at Ivy Pkwy, Atlanta, GA
License number
Georgia 34066
Category
Medical Practice
Type
Research Study
Address
Address
2 Ivy Pkwy NE, Atlanta, GA 30342
Phone
(470) 255-0582
(404) 233-2910 (Fax)
(404) 233-2910 (Fax)
Personal information
See more information about AARON TOMER at radaris.comName
Address
Phone
2 Ivy Pkwy NE, Atlanta, GA 30342
6735 River Springs Ln N, Atlanta, GA 30328
Professional information
See more information about AARON TOMER at trustoria.com
Flow Cytometry Assay For Heparin-Induced Thrombocytopenia
Flow Cytometry Assay For Heparin-Induced Thrombocytopenia
US Patent:
5763201, Jun 9, 1998
Filed:
Sep 3, 1996
Appl. No.:
8/697960
Inventors:
Aaron Tomer - Atlanta GA
Assignee:
Emory University - Atlanta GA
International Classification:
G01N 3353
US Classification:
435 721
Abstract:
The present invention relates to a flow cytometry assay for the determination of heparin-induced thrombocytopenia. This method (a) detects in a plasma sample the presence of anti-heparin antibodies which react with platelets in the presence of heparin to produce activated platelets, (b) quantitates by flow cytometry the presence of such activated platelets in the plasma sample, and (c) correlates the presence of activated platelets with a diagnosis of HIT for the patient. In addition, the flow cytometry assay of the invention is also useful in assessing the compatibility of a heparin-like molecule for use as an alternate therapy for patients with heparin-induced thrombocytopenia. In addition, the invention contemplates a mepacrine release assay with flow cytometry for the detection of heparin-induced thrombocytopenia and for the assessment of compatibility of heparin-like molecules in patients diagnosed with heparin-induced thrombocytopenia.
Flow Cytometry Assay For Heparin-Induced Thrombocytopenia
Flow Cytometry Assay For Heparin-Induced Thrombocytopenia
US Patent:
5939276, Aug 17, 1999
Filed:
Dec 2, 1997
Appl. No.:
8/982811
Inventors:
Aaron Tomer - Atlanta GA
Assignee:
Emory University - Atlanta GA
International Classification:
G01N 33564
US Classification:
435 721
Abstract:
The present invention relates to a flow cytometry assay for the determination of heparin-induced thrombocytopenia. This method (a) detects in a plasma sample the presence of anti-heparin antibodies which react with platelets in the presence of heparin to produce activated platelets, (b) quantitates by flow cytometry the presence of such activated platelets in the plasma sample, and (c) correlates the presence of activated platelets with a diagnosis of HIT for the patient. In addition, the flow cytometry assay of the invention is also useful in assessing the compatibility of a heparin-like molecule for use as an alternate therapy for patients with heparin-induced thrombocytopenia. In addition, the invention contemplates a mepacrine release assay with flow cytometry for the detection of heparin-induced thrombocytopenia and for the assessment of compatibility of heparin-like molecules in patients diagnosed with heparin-induced thrombocytopenia.