Inventors:
Zola P. Horovitz - Princeton NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A01N 4346, A61K 3155, C07D22316, C07D28110
Abstract:
A method is provided for inhibiting loss of cognitive function, including memory, which may or may not be associated with Alzheimer's disease, in a mammalian species by administering a benzazepine-type or a pyrimidine-type calcium channel blocker such as diltiazem, SQ 31,765, SQ 32,324, SQ 33,351, SQ 33,537 or SQ 32,547 alone or in combination with an ACE inhibitor, such as captopril or SQ 29,852, over a prolonged period of treatment.