Inventors:
Daniel C. Chan - Aurora CO, US
Di Zheng - Aurora CO, US
Zhiyong Zhang - Aurora CO, US
Assignee:
The Regents of the University of Colorado, A Body Corporate - Denver CO
International Classification:
C12Q 1/68, C12Q 1/02, C40B 30/00, G01N 33/574, A61K 39/395, A61K 31/713, A61K 31/7088, A61K 38/02, A61P 35/00
US Classification:
4241731, 435 29, 506 7, 435 6, 435 723, 514 44 A, 514 44 R, 514 193
Abstract:
The present invention is based on the finding that the level of KIR expression in a cancer cell is significant with regard to tumor invasion and metastasis. Therefore, the present invention concerns methods and compositions for evaluating cancer in a patient based on KIR protein or mRNA expression. The invention also provides methods and compositions for treating cancer using a KIR inhibitor and methods of screening for KIR inhibitors.