ZHENGPING ZHUANG
Medical Practice in Bethesda, MD
License number
DC MD21188
Category
MEDICINE
Type
MEDICINE AND SURGERY
Address
Address
Bethesda, MD
Personal information
See more information about ZHENGPING ZHUANG at radaris.comName
Address
Phone
10411 Aubinoe Farm Dr, Bethesda, MD 20814
10411 Aubinoe Farm Dr, Bethesda, MD 20814
9904 Pomona Dr, Bethesda, MD 20817
Professional information
Zhengping Zhuang, Bethesda MD
Work:
Mnb/Ninds/Nih
Bldg10 Rm3D20, Bethesda, MD 20892 Mnb/Ninds/Nih
Bldg10 Rm5D37, Bethesda, MD 20892
Bldg10 Rm3D20, Bethesda, MD 20892 Mnb/Ninds/Nih
Bldg10 Rm5D37, Bethesda, MD 20892
Isolation Of Cellular Material Under Microscopic Visualization
US Patent:
6569639, May 27, 2003
Filed:
Jan 18, 2001
Appl. No.:
09/765937
Inventors:
Lance A. Liotta - Potomac MD
Michael E. Buck - Bethesda MD
Rhonda Ann Weiss - Washington DC
Zhengping Zhuang - Bethesda MD
Robert F. Bonner - Washington DC
Michael E. Buck - Bethesda MD
Rhonda Ann Weiss - Washington DC
Zhengping Zhuang - Bethesda MD
Robert F. Bonner - Washington DC
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
G01N 130
US Classification:
435 405, 100 4, 422 681
Abstract:
A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
Isolation Of Cellular Material Under Microscopic Visualization
US Patent:
6204030, Mar 20, 2001
Filed:
Sep 2, 1999
Appl. No.:
9/388805
Inventors:
Lance A. Liotta - Potomac MD
Michael E. Buck - Bethesda MD
Rhonda Ann Weiss - Washington DC
Zhengping Zhuang - Bethesda MD
Robert F. Bonner - Washington DC
Michael E. Buck - Bethesda MD
Rhonda Ann Weiss - Washington DC
Zhengping Zhuang - Bethesda MD
Robert F. Bonner - Washington DC
Assignee:
The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
Department of Health and Human Services - Washington DC
International Classification:
C12P 1912
US Classification:
435100
Abstract:
A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
Isolation Of Cellular Material Under Microscopic Visualization
US Patent:
6010888, Jan 4, 2000
Filed:
Sep 8, 1997
Appl. No.:
8/925894
Inventors:
Lance A. Liotta - Potomac MD
Michael E. Buck - Bethesda MD
Rhonda Ann Weiss - Washington DC
Zhengping Zhuang - Bethesda MD
Robert F. Bonner - Washington DC
Michael E. Buck - Bethesda MD
Rhonda Ann Weiss - Washington DC
Zhengping Zhuang - Bethesda MD
Robert F. Bonner - Washington DC
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
C12P 1912
US Classification:
435100
Abstract:
A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
Use Of Phosphatases To Treat Tumors Overexpressing N-Cor
US Patent:
2008021, Sep 4, 2008
Filed:
Feb 8, 2007
Appl. No.:
11/703401
Inventors:
Zhengping Zhuang - Bethesda MD, US
Edward H. Oldfield - Philmont VA, US
Deric M. Park - Pittsburgh PA, US
Irina Lubensky - Potomac MD, US
Jie Li - Gaithersburg MD, US
John S. Kovach - East Setauket NY, US
Edward H. Oldfield - Philmont VA, US
Deric M. Park - Pittsburgh PA, US
Irina Lubensky - Potomac MD, US
Jie Li - Gaithersburg MD, US
John S. Kovach - East Setauket NY, US
International Classification:
A61K 31/496, C12Q 1/02, G01N 33/50, A61P 35/00
US Classification:
51425501, 435 29, 436 86
Abstract:
This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.
Use Of Phosphatases To Treat Neuroblastomas And Medulloblastomas
US Patent:
2009003, Feb 5, 2009
Filed:
Aug 1, 2008
Appl. No.:
12/221360
Inventors:
John S. Kovach - East Setauket NY, US
Zhengping Zhuang - Bethesda MD, US
Zhengping Zhuang - Bethesda MD, US
International Classification:
A61K 38/46, A61K 31/496, A61K 31/34, A61K 38/02, A61K 38/12, A61P 35/00, A61K 31/07, A61K 38/15, A61K 31/44, A61K 33/16
US Classification:
424 946, 51425501, 514469, 514352, 424676, 514 2, 514 9, 514725
Abstract:
Disclosed herein are methods of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a phosphatase ligand in an amount effective to treat the subject. Also disclosed herein are method of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a histone deacteylase ligand in an amount effective to treat the subject.
Methods For Regulating Cell Mitosis By Inhibiting Serine/Threonine Phosphateses
US Patent:
2010002, Feb 4, 2010
Filed:
Jul 17, 2009
Appl. No.:
12/460407
Inventors:
John S. Kovach - East Setauket NY, US
Zhengping Zhuang - Bethesda MD, US
Jie Lu - Bethesda MD, US
Zhengping Zhuang - Bethesda MD, US
Jie Lu - Bethesda MD, US
International Classification:
A61K 31/496, A61K 31/4525, A61K 31/34, C12Q 1/02, C12N 5/06, A61P 35/00
US Classification:
51425411, 514319, 514469, 435 29, 435375
Abstract:
Disclosed herein are methods of inhibiting proliferation of a cancer cell or inducing apoptosis of a cancer cell, which does not overexpress N—CoR. Also disclosed herein are methods of inhibiting proliferation or inducing apoptosis of a cancer cell that overexpresses TCTP and methods for determining whether a compound is effective in inducing cell death.
Men1
US Patent:
7358347, Apr 15, 2008
Filed:
Mar 4, 1998
Appl. No.:
09/380337
Inventors:
Settara Chandrasekharappa - Gaithersburg MD, US
Pachiappan Manickam - Huntsville AL, US
Francis S. Collins - Rockville MD, US
Michael R. Emmert-Buck - Silver Spring MD, US
Larisa V. Debelenko - New York NY, US
Irina A. Lubensky - Silver Spring MD, US
Lance A. Liotta - Bethesda MD, US
Sunita K. Agarwal - Gaithersburg MD, US
Allen M. Spiegel - Bethesda MD, US
A. Lee Burns - Rockville MD, US
Stephen J. Marx - Chevy Chase MD, US
Zhengping Zhuang - Bethesda MD, US
Pachiappan Manickam - Huntsville AL, US
Francis S. Collins - Rockville MD, US
Michael R. Emmert-Buck - Silver Spring MD, US
Larisa V. Debelenko - New York NY, US
Irina A. Lubensky - Silver Spring MD, US
Lance A. Liotta - Bethesda MD, US
Sunita K. Agarwal - Gaithersburg MD, US
Allen M. Spiegel - Bethesda MD, US
A. Lee Burns - Rockville MD, US
Stephen J. Marx - Chevy Chase MD, US
Zhengping Zhuang - Bethesda MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07H 21/00, C07H 21/02, C07H 21/04, C12Q 1/68, C12P 19/26, C12P 19/34
US Classification:
536 231, 536 235, 536 243, 536 2431, 536 2433, 536 253, 435 6, 435 84, 435 911, 435 912
Abstract:
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.