Inventors:
Dennis J. Slamon - Woodland Hills CA, US
Richard S. Finn - Encino CA, US
Judy Dering - Westlake Village CA, US
J. Randolph Hecht - Los Angeles CA, US
Zev A. Wainberg - Los Angeles CA, US
Edwin A. Clark - Pennington NJ, US
Charles L. Ginther - Los Angeles CA, US
Assignee:
BRISTOL-MYERS SQUIBB COMPANY - Princeton NJ
International Classification:
A61K 31/506, C12Q 1/02, C12Q 1/68, A61P 35/00
US Classification:
51425219, 435 29, 435 611, 435 61
Abstract:
Methods and compositions are provided useful in the diagnosis, treatment and management of cancers wherein cancer cells express certain polynucleotides and/or polypeptides that are differentially expressed in colon cancer subtypes that are sensitive to therapy with abl kinase inhibitors and src kinase inhibitors. In particular, PTK-7, PLK-2 and PLK-3 could be identified as markers for determining the responsiveness of cancer to dasatinib.