Inventors:
Fernanda H. Sakamoto - Boston MA, US
R. R. Anderson - Boston MA, US
Zeina Tannous - Boston MA, US
William A. Farinelli - Danvers MA, US
Apostolos G. Doukas - Belmont MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
International Classification:
A61N 5/06, A61K 31/197, A61P 35/00
Abstract:
The invention provides methods and compositions for treating a tissue disorder in a subject by parenterally administering a solution of aminolevulinic acid (ALA) or a derivative thereof that is not greater than 1.0 percent by weight into a local subcutaneous or dermal region of the subject; and administering high fluence light to said bodily area to produce a phototoxic species in said local region, thereby treating a tissue disorder in the subject.