PROF. ZBYLUT JOZEF TWARDOWSKI, MD
Osteopathic Medicine at Devine Ct, Columbia, MO

6592565, Jul 15, 2003

Apr 26, 2001

09/844578

Zbylut J. Twardowski - Columbia MO 65203

A61M 3100

604500, 604175

The method of selecting and implanting a permanent venous catheter into a patient for use in chronic, extracorporeal blood treatment procedures. The method comprises determining the Body Surface Area of the patient. One then selects a permanent venous catheter having an actual length which is within 10% of a desired length as indicated in a Table found in this application for the Body Surface Area of the particular patient and a particular vein through which the catheter is to extend. Also, the internal diameter of the tubing is preferably adjusted in a manner correlating with the catheter length. Following catheter selection, the venous catheter is implanted in the venous system of the patient with the distal tip of the catheter being in or adjacent to the upper right atrium of the heart.

5209723, May 11, 1993

Oct 8, 1991

7/772613

Zbylut J. Twardowski - Columbia MO
John C. Van Stone - Columbia MO
W. Kirt Nichols - Columbia MO

The Curators of the University of Missouri - Columbia MO

A61M 300

604 43

A multiple lumen, intravenous catheter for hemodialysis or the like defines a distal end portion in which at least a pair of the catheter lumens each communicates with the exterior through aperture means. By this invention the aperture means of one of the lumens defines a first port at essentially the distal catheter end, and the aperture means of the other of the lumens defines a second port spaced proximally along the catheter from the distal end and first port. The second port is positioned to face radially inwardly to at least a slight degree to avoid engagement of the wall of the blood vessel that the catheter occupies. Additionally, the tip of the catheter distal of the second port is preferably of substantially helically shape, being sized to assist in keeping the second port away from the blood vessel wall. As another feature, the catheter may be angled in its as-manufactured, unstressed condition to avoid pressing by elastic memory against internal blood vessel walls. Also, the catheter may define an inflatable balloon positioned between the first and second ports as a means for spacing particularly the second port away from blood vessel walls.

7695450, Apr 13, 2010

Mar 28, 1995

08/412114

Zbylut J. Twardowski - Columbia MO, US
John C. Van Stone - Columbia MO, US
W. Kirt Nichols - Columbia MO, US

Curators of the University of Missouri, The University of Missouri - Columbia MO

A61M 31/00

604 9301

A catheter for hemodialysis comprises a flexible catheter tube defining a plurality of separate lumens. The catheter defines an arc angle of generally U-shape in its natural, unstressed configuration. Thus, the catheter may be implanted with a distal catheter portion residing in a vein of the patient, the distal catheter portion being of substantially the shape of the vein in its natural, unstressed condition. Also, a proximal catheter portion resides in a surgically created tunnel extending from the vein and through the skin of the patient, this section of the catheter also being typically in its natural, unstressed condition. Thus blood may be removed from the vein through one lumen of the catheter, and blood may be returned to the vein through another lumen of the catheter, while the catheter is subject to long term indwelling in the body. Improved results are achieved because of the lack of mechanical stress in the shape of the catheter, which stress causes the catheter to press unduly against adjacent tissues.

5509897, Apr 23, 1996

Feb 15, 1995

8/389283

Zbylut J. Twardowski - Columbia MO
John C. Van Stone - Columbia MO
W. Kirt Nichols - Columbia MO

The Curators of the University of Missouri - Columbia MO

A61M 300

604 43

A catheter for hemodialysis comprises a flexible catheter tube defining a plurality of separate lumens. The catheter defines an arc angle of generally U-shape in its natural, unstressed configuration. Thus, the catheter may be implanted with a distal catheter portion residing in a vein of the patient, the distal catheter portion being of substantially the shape of the vein in its natural, unstressed condition. Also, a proximal catheter portion resides in a surgically created tunnel extending from the vein and through the skin of the patient, this section of the Catheter also being typically in its natural, unstressed condition. Thus blood may be removed from the vein through one lumen of the catheter, and blood may be returned to the vein through another lumen of the catheter, while the catheter is subject to long term indwelling in the body. Improved results are achieved because of the lack of mechanical stress in the shape of the catheter, which stress causes the catheter to press unduly against adjacent tissues.

5405320, Apr 11, 1995

Apr 8, 1993

8/045016

Zbylut J. Twardowski - Columbia MO
John C. Van Stone - Columbia MO
W. Kirt Nichols - Dept. of Surgery University of Missouri Hospital 65212 MO

The Curators of the University of Missouri - Columbia MO

A61M 300

604 43

A catheter for hemodialysis comprises a flexible catheter tube defining a plurality of separate lumens. The catheter defines an arc angle of generally U-shape in its natural, unstressed configuration. Thus, the catheter may be implanted with a distal catheter portion residing in a vein of the patient, the distal catheter portion being of substantially the shape of the vein in its natural, unstressed condition. Also, a proximal catheter portion resides in a surgically created tunnel extending from the vein and through the skin of the patient, this section of the catheter also being typically in its natural, unstressed condition. Thus blood may be removed from the vein through one lumen of the catheter, and blood may be returned to the vein through another lumen of the catheter, while the catheter is subject to long term indwelling in the body. Improved results are achieved because of the lack of mechanical stress in the shape of the catheter, which stress causes the catheter to press unduly against adjacent tissues.

5171227, Dec 15, 1992

Apr 16, 1991

7/686186

Zbylut J. Twardowski - Columbia MO
Ramesh Khanna - Columbia MO
W. Kirt Nichols - Columbia MO
Karl D. Nolph - Columbia MO

The Curators of the University of Missouri - Columbia MO

A61M 532, A61M 2500

604175

A peritoneal dialysis catheter comprises a distal tubular section and a proximal tubular section, connected together by a nonintegral tubular connector so that the respective sections are connected together in sealed flow relation. Such a catheter may be surgically implanted in the peritoneal cavity, extending to the chest of the patient with an end thereof protruding from the chest. The respective ends of the catheter section may be connected to each other through the tubular connector as the tubular sections are surgically implanted, and typically after such implantation is substantially complete.

5961486, Oct 5, 1999

Nov 5, 1998

9/187100

Zbylut J. Twardowski - Columbia MO
W. Kirt Nichols - Columbia MO
John C. Van Stone - Columbia MO

A61M 300

604 43

Blood is circulated through a multiple lumen catheter which connects between a vein of a patient and the blood treatment device. The catheter and the lumens thereof each define distal ends which are positioned within the vein. By this invention, one withdraws blood from the vein through one of the lumens at a flow rate of at least about 200 ml. /min. while also inserting blood into the vein through another of said lumens at a similar flow rate. The distal ends of the lumens are longitudinally spaced from each other by no more than about 5 mm. It has been found that the following advantages can be achieved by this method: less clot formation coupled with low direct blood recirculation and longer catheter survival. Also, the catheter of this invention works well in either direction of blood flow through the respective lumens.

5902476, May 11, 1999

Mar 28, 1997

8/829537

Zbylut J. Twardowski - Columbia MO

B01D61/28

210143

A hemodialyzer apparatus comprises a reusable dialyzer membrane as well as reusable blood flow path and dialysis flow path units. The apparatus automatically primes itself and makes dialysis solution from dry chemicals, concentrates, and fresh water which is provided to the apparatus. Also, after use, the apparatus automatically prepares cleaning and rinsing solution for the cleaning and rinsing of the dialyzer membrane as well as the dialyzate and blood flow path means, to provide a system which is so simplified in terms of automatic operation that it may be usable for daily dialysis at home.

4604379, Aug 5, 1986

Jun 18, 1984

6/621392

Zbylut J. Twardowski - Columbia MO
Karl D. Nolph - Columbia MO

Curators of the University of Missouri - Columbia MO

C08L 8904, C08L 8906, C09H 700

514 21

Peritoneal dialysis solution may have an osmotic agent as a partial or complete substitute to the conventional dextrose. The osmotic agent is gelatin chemically cross-linked to suppress gelation.