Inventors:
Ralph R. Weichselbaum - Chicago IL, US
Zahra Shafaee - Bronxville NY, US
Wei Du - Chicago IL, US
Assignee:
The University of Chicago - Chicago IL
International Classification:
A61K 31/337, A61P 35/00, C12N 5/02
Abstract:
The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.