Inventors:
Ravindra K. Pandey - Williamsville NY, US
Zachary Grossman - Buffalo NY, US
Peter Kanter - East Aurora NY, US
Thomas J. Dougherty - Grand Island NY, US
Assignee:
Health Research, Inc. - Buffalo NY
International Classification:
A61B 5/055
US Classification:
424 93, 424 111, 424 165, 424 91, 540145
Abstract:
A method for MR imaging that comprises conducting the MR imaging after injecting compositions that are chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium, Gadolinium, Indiumand radioactive iodine. When the element can form cations, the compound is usually a chelate with the porphyrin or chlorin structure. When the element forms anions, the compound is usually a direct chemical combination of the radioactive element into the porphyrin or chlorin structure. The method uses the compounds of the invention for diagnostic imaging of hyperproliferative tissue such as tumors and new blood vessel growth as is associated with the wet form of age related macular degeneration and methods of making the compounds. Compounds for MRI contrast imaging of the invention are usually Tc, Inor Gd(III) complexes of compounds of the formula:.