Inventors:
Yun Wang - Chestnut Hill MA, US
Assignee:
Caritas St. Elizabeth's Medical Center - Boston MA
International Classification:
A61K 38/17, A61K 38/04
Abstract:
The present invention relates to a novel method of inhibiting gap junction-mediated signaling in pyramid cells. Pyramidal gap junctions are quickly and reversibly inhibited by beta-amyloid or biologically active fragments thereof. The present invention also relates to the use of beta-amyloid as an anticonvulsant for the treatment of epilepsy and other pathological hypersynchrony conditions in humans and non-human animals.