Inventors:
James M. Cook - Milwaukee WI, US
Terry S. Clayton - Colorado Springs CO, US
Hiteshkumar D. Jain - Kurla, IN
Yun Teng Johnson - Glendale WI, US
Jie Yang - Renssalaer NY, US
Michael Ming-Jin Poe - Milwaukee WI, US
Ojas A. Namjoshi - Cary NC, US
Zhi-jian Wang - Whitefish Bay WI, US
Assignee:
UWM RESEARCH FOUNDATION, INC. - Milwaukee WI
International Classification:
A61K 31/5517, A61P 25/18, A61P 25/22, A61P 25/08, C07D 487/04, C07D 487/14
US Classification:
514220, 540498, 540562, 540494, 514219
Abstract:
Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.