Young T Kim
Architects in West Concord, MA
License number
Massachusetts 951063
Issued Date
Nov 14, 2016
Expiration Date
Aug 31, 2017
Type
Architect
Address
Address
West Concord, MA 01742
Professional information
System And Method For Determining Blood-Brain Barrier Permeability To Water
US Patent:
2012017, Jul 12, 2012
Filed:
Sep 13, 2011
Appl. No.:
13/230990
Inventors:
Peter Caravan - Cambridge MA, US
Young Ro Kim - Concord MA, US
A. Gregory Sorensen - Belmont MA, US
Young Ro Kim - Concord MA, US
A. Gregory Sorensen - Belmont MA, US
International Classification:
A61B 5/055
US Classification:
600420
Abstract:
A method is provided for measuring a permeability of a subject's blood-brain barrier to water. The method includes acquiring, with an magnetic resonance imaging (“MRI”) system, a first Tmap of the subject over at least a selected region-of-interest (“ROI”) including a brain of the subject and waiting a delay period selected to allow an affect of the contrast agent on the longitudinal relaxation period to change. The method then includes acquiring, after expiration of the delay period and with the MRI system, a second Tmap of the subject over at least the selected ROI and determining, using the first Tmap and the second Tmap, a fractional volume of vascular compartments in the ROI and a permeability surface area product in the ROI. The method includes creating, using the determined fractional volume and permeability surface area product, a map of water exchange rate in the ROI.