You H Bae
Hearing Aid Provider in Salt Lake City, UT

5262055, Nov 16, 1993

Oct 19, 1992

7/962879

You H. Bae - Salt Lake City UT
Sun W. Kim - Salt Lake City UT

The University of Utah - Salt Lake City UT

B01D 6100, B01D 6308, B01D 6906

210645

An artificial pancreas system which minimizes the volume of the artificial pancreas by not encapsulating each islet is taught wherein the islets are separated and held within a polymeric matrix which is soluble in an aqueous solution below body temperature but insoluble in aqueous solutions at or above body temperature. The polymer-islet mixture is contained in a pouch having access means such as entry and exit ports. The solubility makes it possible to replace the contents of the pouch by solubilizing the matrix simply by lowering the temperature below the LCST. The pouch is constructed of a biocompatible material permeable to insulin and other substances of similar or lesser molecular weight but is impermeable to cellular and humoral components of the body immune system. The islet-polymer matrix can be functionalized to stimulate insulin secretion from the islets using insulinotropic agents such as sulfonylurea. Also, polymeric microparticles which release bioactive agents which either promote vascularization at the pouch membrane outer surface or inhibit macrophage activity can be added to the polymer matrix.

2010005, Mar 4, 2010

Sep 1, 2009

12/552190

Darrell R. Fisher - Richland WA, US
You Han Bae - Salt Lake City UT, US
Zhonggao Gao - Salt Lake City UT, US

Battelle Memorial Institute - Richland WA
University of Utah Research Foundation - Salt Lake City UT

A61M 36/12

600 8

A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.

2010005, Mar 4, 2010

Sep 2, 2008

12/202954

Darrell R. Fisher - Richland WA, US
You Han Bae - Salt Lake City UT, US

A61M 36/12

600 8

A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved or broken so as to release the microspheres. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.

5226902, Jul 13, 1993

Jul 30, 1991

7/737675

You H. Bae - Salt Lake City UT
Sung W. Kim - Salt Lake City UT
Lev I. Valuev - Moscow, SU

University of Utah - Salt Lake City UT

A61K 922

6048921

A device for the dispensing of a biologically active material into the surrounding environment is disclosed which consists of at least one wall enclosing a compartment which contains a swollen stimuli sensitive hydrogel in which the biologically active material is entrained in solution. The hydrogel deswells or shrinks in response to contact by external physical or chemical stimuli releasing the biologically active material into the portion of the compartment previously occupied by the swollen hydrogel. The wall enclosing the compartment is rigid and contains means allowing the passage of the biologically active material from the compartment to the surrounding environment and also for transmitting the external stimuli to the swollen hydrogel in said compartment. The wall may contain orifices or be permeable to the active material and external stimuli depending upon the drug and the stimuli to be used. The hydrogel reversibly deswells, shrinks or contracts in response to stimuli, such as temperature, pH, ionic strength, glucose concentration or metabolites in the body and then reswells and reentrains active material not diffused from the compartment when the stimuli is removed.

7951846, May 31, 2011

May 4, 2009

12/435283

You Han Bae - Salt Lake City UT, US
Kun Na - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US

A61K 47/00, A61K 9/00, A01K 25/00

5147721, 424400, 514772

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.

2011002, Feb 3, 2011

Jul 28, 2009

12/510541

You Han Bae - Salt Lake City UT, US
Halqing Yin - San Lake City UT, US

A61K 9/127, C07C 233/01, C07K 7/06, C07K 7/08, C07K 14/00

424450, 564192, 530330, 530329, 530328, 530327, 530326, 530324, 530402

Described herein is the synthesis and pharmacology of polymersomes containing one or more bioactive agents. The polymersome is generally derived from a polymer having the formula XY, wherein X includes a hydrophilic group and Y includes a hydrophobic group. Also described herein are methods for making and using the polymersomes as drug delivery devices.

7786220, Aug 31, 2010

Jan 26, 2005

10/590959

Doo Sung Lee - Gyeonggi-do, KR
Woo Sun Shim - Gyeonggi-do, KR
You Han Bae - Salt Lake City UT, US
Je Sun You - Gyeonggi-do, KR
Min Sang Kim - Gyeonggi-do, KR
Huynh Dai Phu - Gyeonggi-do, KR

Sungyunkwan University Foundation for Corporate Collaboration - Suwon-si

C08L 77/00

525408, 424426, 424486, 514601, 514602, 514603, 514604, 524609, 524612, 524916

The present invention relates to a block copolymer formed by coupling the following components with each other, as well as a hydrogel composition comprising the block copolymer and a hydrogel formed from the composition: (a) a copolymer of a polyethylene glycol (PEG)-based compound with a biodegradable polymer; and (b) a sulfonamide-based oligomer. The inventive block copolymer shows the sol-gel transition behavior sensitive to changes in not only temperature but also pH. Thus, the inventive block copolymer overcomes the shortcomings of temperature-sensitive copolymers, form a more strong and stable hydrogel, and is stable in vivo. Accordingly, the inventive block copolymer can be used in various applications in the medical and drug delivery fields.

7659314, Feb 9, 2010

May 14, 2004

10/846487

You Han Bae - Salt Lake City UT, US
Kun Na - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

A61K 47/00, A61K 9/00, A01K 25/00

5147721, 424400, 514772

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.

2008021, Sep 4, 2008

Nov 30, 2007

11/998841

You Han Bae - Salt Lake City UT, US
Kun Na - Suwon, KR
Eun Seung Lee - Suwon, KR

A61K 9/14

424490

Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature.

6268161, Jul 31, 2001

May 11, 1999

9/308392

In Suk Han - Salt Lake City UT
You Han Bae - Salt Lake City UT
Jules J. Magda - Salt Lake City UT
Seong Gi Baek - Woodbury MN

M-Biotech, Inc. - Salt Lake City UT

C12Q 154, C12M 134

435 14

A biosensor (10) has a pH-sensitive polymeric hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized oxidoreductase enzyme such as glucose oxidase. The oxidoreductase enzyme catalyzes a chemical reaction consuming an organic molecule and producing a byproduct. The hydrogel (30) changes its osmotic pressure in proportion to the concentration of a byproduct. By measuring the change in osmotic pressure with a pressure transducer (40), the biosensor (10) is able to accurately measure the concentration of the organic molecule without the problem of interference encountered by prior art biosensors. A battery (64) powered telemeter (60) operably engaged to the pressure transducer (40) sends a radio data signal to a receiver (66) operably attached to a computer (62).