YOGISH C KUDVA, MBBS
Osteopathic Medicine at 1 St, Rochester, MN

2013021, Aug 15, 2013

Oct 26, 2012

13/661755

Universita degli Studi di Padova - , US
Mayo Foundation for Medical Education and Rese - , US
Michele Schiavon - Chioggia, IT
Ananda Basu - Rochester MN, US
Yogish C. Kudva - Rochester MN, US

Mayo Foundation for Medical Education and Research - Rochester MN

A61B 5/00, A61B 5/1495, A61B 5/145

600365

In a method of determining insulin sensitivity in a patient, glucose level is sensed continuously. A first area under the curve representing the glucose level over time is calculated. An amount of insulin that has been administered to the patient is sensed. An estimation of insulin on board the patient is calculated based on the glucose level and the amount of insulin administered to the patient. A second area under the curve representing the insulin on board over time is calculated. Patient data indicative of at least one patient physical parameter is received. Information indicative of amount of glucose ingested by the patient during a meal is received. An insulin sensitivity output indicative of ability of insulin to stimulate glucose utilization and inhibit glucose production in the patient based on the first and second area under the curve, the patient data and the meal information is generated.

2013002, Jan 31, 2013

Jul 19, 2012

13/553064

Tayaramma Thatava - Rochester MN, US
Andre Terzic - Rochester MN, US
Yogish C. Kudva - Rochester MN, US
Yasuhiro Ikeda - Rochester MN, US

C12N 5/071, C12N 5/078, C12N 5/079, C12N 5/077

435366, 435377, 435325

This document provides methods and materials related to differentiating iPS cells into glucose-responsive, insulin-secreting progeny. For example, methods and material for using indolactam V (ILV) and glucagon like peptide-1 (GLP-1) to produce glucose-responsive, insulin-secreting progeny from iPS cells are provided.