YI ZHANG, GNP
Nursing at 33 Ave, Minneapolis, MN

7993280, Aug 9, 2011

Jul 30, 2010

12/847645

Yi Zhang - Plymouth MN, US
John D. Hatlestad - Maplewood MN, US
Yousufali H. Dalal - Irvine CA, US
Marina Brockway - Shoreview MN, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61B 5/08

600529, 600484

Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.

2009023, Sep 17, 2009

Mar 11, 2009

12/402224

Dan Li - Shoreview MN, US
Haresh G. Sachanandani - Los Angeles CA, US
Michael John Kane - Clonmel, IE
Yi Zhang - Plymouth MN, US

CARDIAC PACEMAKERS, INC. - St. Paul MN

A61B 5/1468, A61B 5/04

600345, 600516

Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

8005540, Aug 23, 2011

Jul 14, 2010

12/836441

Yi Zhang - Plymouth MN, US
John D. Hatlestad - Maplewood MN, US
Gerrard M. Carlson - Champlin MN, US
Yousufali Dalal - Irvine CA, US
Marina V. Brockway - Shoreview MN, US
Kent Lee - Shoreview MN, US
Richard O. Kuenzler - Shaker Heights OH, US
Carlos Haro - St. Paul MN, US
Krzysztof Z. Siejko - Maple Grove MN, US
Abhilash Patangay - Inver Grove Heights MN, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61N 1/02

607 3, 600301

The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

2011007, Mar 24, 2011

Sep 23, 2010

12/888900

Yi Zhang - Plymouth MN, US
Shibaji Shome - Minneapolis MN, US
Kritika Gupta - Durham NC, US
Dan Li - Shoreview MN, US
Julie A. Thompson - Circle Pines MN, US

A61B 5/0452, A61N 1/365

600509, 607 17

An apparatus comprises an ambulatory cardiac signal sensing circuit configured to provide an electrical cardiac signal representative of cardiac activity of a subject and processor. The processor includes a feature module, a correlation module, and an ischemia detection module. The feature module is configured to identify a fiducial feature in the cardiac signal and locate one or more cardiac features in the cardiac signal using the fiducial feature. The correlation module is configured to calculate a measure of similarity of morphology for a segment of the cardiac signal that includes the cardiac features. The ischemia detection module is configured to detect a change in the measure of similarity and determine whether the detected change in the measure of similarity is indicative of ischemia.

8116871, Feb 14, 2012

Mar 23, 2009

12/409348

Yi Zhang - Plymouth MN, US
Jiang Ding - Shoreview MN, US
Aaron McCabe - Minneapolis MN, US
Scott A. Meyer - Lakeville MN, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61N 1/08, A61N 1/37, A61B 5/0452

607 28, 600512

Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

8321003, Nov 27, 2012

Jul 23, 2009

12/508398

Yi Zhang - Plymouth MN, US
Kenneth C. Beck - St. Paul MN, US
Aaron Lewicke - Forest Lake MN, US
Yunlong Zhang - Mounds View MN, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61B 5/04

600513, 600509

Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

2010019, Jul 29, 2010

Feb 19, 2010

12/708655

Aaron Lewicke - Forest Lake MN, US
Yi Zhang - Plymouth MN, US
John D. Hatlestad - Maplewood MN, US

A61B 5/0205, A61B 5/08

600301, 600529

A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.

2013019, Aug 1, 2013

Mar 13, 2013

13/798684

Aaron R. McCabe - Edina MN, US
Imad Libbus - St. Paul MN, US
Yi Zhang - Plymouth MN, US
Paul A. Haefner - Circle Pines MN, US
Alok S. Sathaye - New York NY, US
Anthony V. Caparso - San Jose CA, US
M. Jason Brooke - Woodstock MD, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61N 1/36

607 5, 607 11

Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

2010027, Oct 28, 2010

Apr 15, 2010

12/761018

Abhilash Patangay - Inver Grove Heights MN, US
Yi Zhang - Plymouth MN, US
Aaron Lewicke - Forest Lake MN, US
Julie A. Thompson - Circle Pines MN, US

A61B 5/021, A61B 5/02

600485, 600508

Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.