Inventors:
Richard Marchase - Birmingham AL, US
Pam Bounelis - Birmingham AL, US
John Chatham - Birmingham AL, US
Irshad Chaudry - Birmingham AL, US
Yi Pang - Chicago IL, US
Assignee:
UAB RESEARCH FOUNDATION - Birmingham AL
International Classification:
A61K 35/12, A61K 31/70, A61K 31/7008, A61B 17/00, A01N 1/02, A61K 31/164
US Classification:
424 937, 514 25, 514 62, 514563, 435 11, 128898
Abstract:
Disclosed herein are compositions and methods for preserving cell, tissue, or organ transplants and cultures by increasing the concentration of an intracellular metabolite of the hexosamine biosynthetic pathway. Also described herein are methods of reducing pathogenic effects in a subject by increasing the concentration of an intracellular metabolite of the hexosamine biosynthetic pathway.