YI D YANG
Broker in Cambridge, MA
License number
Massachusetts 9538582
Issued Date
Oct 15, 2015
Expiration Date
May 1, 2018
Type
Salesperson
Address
Address
Cambridge, MA 02141
Professional information
Methods For The Production Of Cells And Mammals With Desired Genetic Modifications
US Patent:
7518033, Apr 14, 2009
Filed:
Aug 1, 2003
Appl. No.:
10/521634
Inventors:
Brian Seed - Boston MA, US
Yi Yang - Cambridge MA, US
Yi Yang - Cambridge MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A01K 67/00, A01K 67/033, A01K 67/027
US Classification:
800 21, 800 8, 800 18
Abstract:
The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an artificial chromosome having a modification of interest and an endogenous chromosome of a cell. The resulting modified cells can be used in standard methods to generate genetically modified mammals. These mammals can be used in a variety of screening methods to identify compounds useful for the treatment or prevention of disease. Additionally, cells that have been modified to eliminate a mutation associated with a disease can be transplanted into patients for the treatment of a disease.