YEON S AHN, MD
Osteopathic Medicine at 12 Ave, Miami, FL

4728660, Mar 1, 1988

Jun 11, 1984

6/619212

Duncan H. Haynes - Miami FL
Wenche Jy - Miami FL
Yeon S. Ahn - Miami FL
William J. Harrington - Miami FL

University of Miami - Coral Gables FL

A61K 31455, G01N 3349, C12Q 156

514356

Calcium (Ca. sup. 2+) channel blockers, such as nifedipine and verapamil, are used in the treatment of thromboembolic diseases such as stroke and peripheral vascular occlusive diseases, especially arterial and venous thrombosis, vasculitis, myelofibrosis disease and hemolytic anemias. Such diseases arise from platelet hyperactivation and the Ca. sup. 2+ channel blockers restore the platelets to their normal aggregation characteristics. Diagnostic procedures for detecting platelet hyperactivation and defective calcium handling/transport indicative of certain peripheral obstructive diseases using chlorotetracycline as a detectable fluorescent probe as a means of assessing a patient's response to Ca. sup. 2+ channel blockers in the therapy of such diseases are also described.

2013031, Nov 28, 2013

Jan 27, 2012

13/982224

Yeon S. Ahn - Miami FL, US
Lawrence L. Horstman - Miami FL, US
Wenche Jy - Miami FL, US

UNIVERSITY OF MIAMI - Miami FL

A61K 35/18

424533, 435325

Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as universal hemostatic agents. Effective RMP are produced from red blood cells using a high-pressure extrusion membrane shear process. The RMP can be lyophilized after production and retain activity even when stored at room temperature. RMP can be administered to original donors (autologous treatment), thus avoiding transfusion complications, or can be administered to blood type compatible recipients. RMP produced from type O, Rh negative red cells can be given to any person regardless of blood type. RMP can be administered to reduce excessive bleeding resulting from trauma, surgeries, invasive procedures and various bleeding disorders such as platelet disorders, either congenital or acquired, and coagulation disorders, either congenital or acquired. Administration of RMP prepared according to the invention demonstrates effectiveness in safely reducing bleeding.

8105632, Jan 31, 2012

Dec 7, 2005

11/792399

Wenche Jy - Miami FL, US
Joaquin J. Jimenez - Miami FL, US
Lawrence L. Horstmann - Miami FL, US
Yeon S. Ahn - Miami FL, US
Eugene Ahn - Miami FL, US

University of Miami - Miami FL

A61K 35/18

424533, 424 9373, 424529

Compositions comprising membrane-derived and synthetic microparticles that induce platelet aggregation and are useful for treating bleeding disorders, particularly those involving platelet dysfunction. Microparticles include endothelial derived microparticles (EMP), platelet derived microparticles (PMP), erythrocyte derived microparticles (RMP), and synthetic microparticles (SMP), and are used to treat disorders such as thrombocytopenia caused by chemotherapy.

4835146, May 30, 1989

Jun 8, 1987

7/059439

William J. Harrington - Miami FL
Yeon S. Ahn - Miami FL
Ravindra Mylvaganam - Miami FL

University of Miami - Coral Gables FL

A61K 3158

514176

Treatment of sickle cell disease using danazol.

4837212, Jun 6, 1989

Dec 1, 1986

6/936957

William J. Harrington - Miami FL
Yeon S. Ahn - Miami FL
Ravindra Mylvaganam - Miami FL

University of Miami - Coral Gables FL

A61K 3158

514176

Danazol, a known androgen, is used to (1) correct immune abnormalities associated with hemotologic disorders or (2) treating immune disorders associated with depressed T helper cells, in the invention disclosed.