Inventors:
Thi-Sau Migone - Gaithersburg MD, US
Jerry L. Klein - Rehoboth Beach DE, US
Yasuhiro Oki - Houston TX, US
Anas Younes - Houston TX, US
Assignee:
Human Genome Sciences, Inc. - Rockville MD
Board of Regents, The University of Texas System - Austin TX
International Classification:
G01N 33/53, G01N 33/564, G01N 33/566, G01N 33/96, C07K 14/435, C07K 16/18
US Classification:
435 71, 435 4, 435 78, 435 792, 436501, 530350, 5303871, 53038823, 5303891, 530399
Abstract:
The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.