Inventors:
Luis Z. Avila - Arlington MA, US
Clark Q. Pan - Sudbury MA, US
Patrick Finn - Weymouth MA, US
John Harrahy - Medway MA, US
Qun Zhou - Ashland MA, US
Yunxiang Zhu - Wayland MA, US
Paul A. Konowicz - Maynard MA, US
Duncan E. Paterson - Zurich, CH
Andreas Peer - Basel, CH
Joseph P. Kutzko - Southborough MA, US
Michael R. Reardon - North Attleboro MA, US
James E. Stefano - Hopkinton MA, US
Xiaoyang Zheng - Newton MA, US
Robert J. Miller - E. Bridgewater MA, US
Lauren Young - Hampton NH, US
International Classification:
A61K 38/43, C12N 9/96, A61P 3/00, C07H 1/00, C08B 37/00, C07K 2/00, A61K 38/02
US Classification:
424 943, 530395, 435188, 514 209, 536 171, 536 182
Abstract:
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.