XIAOSONG ZHANG, MD, PHD
Osteopathic Medicine at Parnassus Ave, San Francisco, CA
License number
California A124474
Category
Osteopathic Medicine
Type
Hematology & Oncology
Address
Address
505 Parnassus Ave, San Francisco, CA 94143
Phone
(415) 885-7276
Personal information
See more information about XIAOSONG ZHANG at radaris.comName
Address
Phone
20800 Valley Green Dr APT 449, Cupertino, CA 95014
3725 Big Dalton Ave, Baldwin Park, CA 91706
5613 River Way, Buena Park, CA 90621
Professional information
See more information about XIAOSONG ZHANG at trustoria.com
Medulloblastoma Genes As Targets For Diagnosis And Therapeutics
Medulloblastoma Genes As Targets For Diagnosis And Therapeutics
US Patent:
2013029, Nov 7, 2013
Filed:
Nov 8, 2011
Appl. No.:
13/884154
Inventors:
Bert Vogelstein - Baltimore MD, US
Kenneth Kinzler - Baltimore MD, US
Nickolas Papadopoulos - Towson MD, US
Donald Williams Parsons - Bellaire TX, US
Rebecca J. Leary - Baltimore MD, US
Meng Li - San Francisco CA, US
Xiaosong Zhang - San Francisco CA, US
Sian Jones - Baltimore MD, US
Gregory J. Riggins - White Hall MD, US
Victor Velculescu - Dayton MD, US
Kenneth Kinzler - Baltimore MD, US
Nickolas Papadopoulos - Towson MD, US
Donald Williams Parsons - Bellaire TX, US
Rebecca J. Leary - Baltimore MD, US
Meng Li - San Francisco CA, US
Xiaosong Zhang - San Francisco CA, US
Sian Jones - Baltimore MD, US
Gregory J. Riggins - White Hall MD, US
Victor Velculescu - Dayton MD, US
International Classification:
C12Q 1/68
US Classification:
514 44 R, 435 611, 435 71
Abstract:
Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.